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doi: 10.1007/s00217-016-2643-y

The burst release might be due to the initial swelling of the nanofibers and/or accumulation of the drug molecules on the nanofiber surface (QS) or at the interface of the core and shell phases (LEV) during electrospinning

164 In a randomized crossover trial in 50 subjects with male infertility, one month of treatment with a supplement containing pine bark extract plus L-arginine (an amino acid precursor to nitric oxide which regulates blood vessel function) increased semen volume, sperm number and concentration, motility, and vitality, and improved sperm morphology compared with placebo